![]() Furthermore, the RORs appear to be constitutively active (absence of ligand) and that activity may be due to continuously bound natural ligands. ![]() While the identity of natural ligands for the RORs remains controversial, similar to the liver X receptors (LXRs), it appears that the RORs are activated by oxysterols. They bind to DNA elements called ROR response elements (RORE). The RORs are somewhat unusual in that they appear to bind as monomers to hormone response elements as opposed to the majority of other nuclear receptors which bind as dimers. There are three forms of ROR, ROR-α, -β, and -γ and each is encoded by a separate gene RORA, RORB, and RORC respectively. ![]() The RAR-related orphan receptors ( RORs) are members of the nuclear receptor family of intracellular transcription factors. Members of the nuclear receptor family of intracellular transcription factors RAR-related orphan receptor A (alpha) ![]()
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